Rezulin

FDA removed Rezulin from the market after its review of early 2000 data on Rezulin and two similar drugs, rosiglitazone (Avandia) and pioglitazone (Actos), showed that Rezulin is more toxic to the liver than the other two drugs. Data to date show that Avandia and Actos, both approved in 1999, offer the same benefits as Rezulin without the same risk.

What is Rezulin?

Rezulin is a medication used in combination with insulin or sulfonylurea in patients with type II diabetes (adult-onset diabetes mellitus) whose blood glucose levels are not adequately controlled by these other therapies alone.

What is Diabetes Mellitus- Type 2?

Type 2 diabetes is a serious, life-threatening disease that affects 18 million Americans. It is a leading cause of coronary heart disease, blindness, kidney failure, and limb amputation. Adequate control of blood sugar appears to be the most important means of preventing these complications.

What health problems has Rezulin been associated with?

• Liver failure
• Liver transplant
• Serious liver damage
• Liver dysfunction

What are the symptoms of liver dysfunction?

• Jaundice (yellow skin or eyes)
• Abdominal pain
• Unusual fatigue
• Loss of appetite or significant weight loss
• Nausea/ Vomiting
• Dark Urine

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