Meridia
On March 19, 2002, the consumer advocacy group, Public Citizen, asked the FDA to take the diet drug, meridia, off the market. The group contends that the drug has been linked to the deaths of more than 25 patients since it first hit the market in 1988. Most of these deaths appear to be related to cardiovascular problems experienced while taking the drug. Meridia was suspended in Italy in March of 2002 because of two cardiovascular deaths related to the drug. There have also been reports of deaths related to the use of meridia in Britain, and there have been 103 reports of serious adverse reactions from people taking the drug in France and Britain. The first meridia lawsuit was filed at the end of March 2002.
What type of drug is Meridia?
Meridia (sibutramine) is a reuptake inhibitor and weight loss agent.
How does Meridia work?
Meridia inhibits the uptake of the neurotransmitters monamine, norepinephrine, 5-HT, and possibly dopamine. Leaving these neurotransmitters more available to aid transmission of nerve impulses has the effect of reducing appetite and depression.
What are the contraindications in using Meridia?
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Hypersensitivity to butramine
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Pregnancy
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Anorexia nervosa
When should caution be exercised in using Meridia?
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Impaired hepatic function
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Hypertension
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Arrhythmias (irregular heart rhythm)
What is the usual dose of Meridia?
Initial dose is 10mg/day. Daily dose may be increased up to 15mg if tolerated.
What are some of the side effects of Meridia?
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Headache
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Nervousness
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Sleep difficulties
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Dry mouth
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Nausea
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Anorexia
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Hypertension
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Tachycardia (high heart rate)
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Arrhythmias (irregular heart rhythm)
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Rash
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Dry shin
What drugs should not be taken with Meridia?
MAO inhibitors should not be taken with or within fourteen days of beginning or stopping meridia.
Use of alcohol and/or CNS (central nervous system) stimulants while taking meridia may increase CNS effects of meridia.
What problems have been reported concerning the use of Meridia?
Meridia has been reportedly linked to the deaths of 25 patients.
Of these deaths, 16 were reportedly related to heart problems
that could have been caused by taking meridia.
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